SLCO1B7 Membrane Protein Introduction

Introduction of SLCO1B7

SLCO1B7, the official full name is solute carrier organic anion transporter family member 1B7. It is encoded by the SLCO1B7 gene in humans and belongs to SLC21A family of solute carriers. 13 organisms have orthologs with this gene. It’s mainly expressed in the endoplasmic reticulum (ER) of the liver and is involved in the uptake of organic anions. The truncated protein of SLCO1B7 will be non-functional, and it’s associated with clozapine-associated neutropenia.

Basic Information of SLCO1B7
Protein Name	Solute carrier organic anion transporter family member 1B7
Gene Name	SLCO1B7
Aliases	LST3, LST3TM12, SLC21A21
Organism	Homo sapiens (Human)
UniProt ID	G3V0H7
Transmembrane Times	12
Length (aa)	640
Sequence	MKISTTQIERRFEISSSLVGLIDGSFEIGNLFVIVFVSYFGSKLHRPKLIGIGCFLMGTGSILMALPHFFMGYYRYSKETNIDPSENSTSNLPNCLINQMLSLNRTPSEIIERGCVKESGSHMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGTVNVMGMTGLVFAFMLGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGIVSIISSIPFFFLPLNPNKPQKERKVSLFLHVLKTNDKRNQIANLTNRRKYITKNVTGFFQSLKSILTNPLYVIFVIFTLLHMSSYIASLTYIIKMVEQQYGWSASKTNFLLGVLALPAVAIGMFSGGYIIKKFKLSLVGLAKLAFCSATVHLLSQVLYFFLICESKSVAGLTLTYDGNSPVRSHVDVPLSYCNSECNCDESQWEPVCGNNGITYLSPCLAGCKSSSGNKEPIVFYNCSCVEVIGLQNKNYSAHLGECPRDDACTRKSYVYFVIQVLDAFLCAVGLTSYSVLVIRIVQPELKALAIGFHSMIMRSLGGILVPIYFGALIDTTCMKWSTNSCGARGACRIYNSTYLGRAFFGLKVALIFPVLVLLTVFIFVVRKKSHGKDTKVLENERQVMDEANLEFLNDSEHFVPSAEEQ

Function of SLCO1B7 Membrane Protein

SLCO1B7 is also known as solute carrier family 21 member 21, which belongs to SLC21A family of solute carriers. This gene encodes an organic anion transporter located in the endoplasmic reticulum and plasma membrane. SLCO1B7 mediates cellular uptake of organic anions in the liver specifically. This transmembrane transporter is particularly known for the functional role in pharmacokinetics. The mRNA LST-3TM12 is a functional splice variant transporter of SLCO1B7 in the ER of the human liver. Cellular accumulation of dehydroepiandrosterone sulfate and estradiol 17β-glucuronide will be enhanced when LST-3TM12 is overexpressed. In addition, SLCO1B7 is associated with adverse drug reactions including docetaxel-induced neutropenia and simvastatin-induced myopathy. Clozapine may lead to serious adverse effect through the relevant biological pathways associated with SLCO1B7.

Fig.1 Model of the transmembrane transporter LST-3TM12. (Malagnino, 2018)

Application of SLCO1B7 Membrane Protein in Literature

Legge S.E., et al. Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia. Mol Psychiatry. 2017, 22(10): 1502-1508. PubMed ID: 27400856

This article indicates that clozapine may lead to serious adverse effects through the relevant biological pathways associated with SLCO1B7.
Malagnino V., et al. LST-3TM12 is a member of the OATP1B family and a functional transporter. Biochem Pharmacol. 2018, 148: 75-87. PubMed ID: 29248594

This article demonstrates that LST-3TM12 is a functional splice variant transporter of SLCO1B7 in the ER of the human liver.
Sreedharan S., et al. Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters. Gene. 2011, 478(1-2): 11-8. PubMed ID: 21044875

This article indicates that SLC21A21 is only present in mammals rather than bilateral species.
Buch S., et al. Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition. Gastroenterology. 2010, 139(6): 1942-1951.e2. PubMed ID: 20837016

This article shows that LST-3TM12 loci are associated with serum levels of bilirubin and gallstone composition.

SLCO1B7 Preparation Options

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Reference

Malagnino V, et al. (2018). LST-3TM12 is a member of the OATP1B family and a functional transporter. Biochem Pharmacol. 148: 75-87.

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