Synthetic Polymer Binding Peptide Screening Service

Creative Biolabs is an industry leader in the field of phage display technology. We can provide the best services of phage display library construction and phage display library screening. Our scientists have developed phage display platform to provide various excellent biopanning strategies for different purposes. The tailored biopanning strategy and proprietary protocol allow the increasing identification of synthetic polymers binding peptides with higher affinity and desired specificity. We are proud to use our extensive experience and advanced platform to offer this top-quality service for all of our global customers.

The Application of Synthetic Polymers in Biomedical Fields

The interfaces between synthetic polymers and binding peptides attract more and more attention to develop novel polymer materials utilized in biomedical ﬁelds, in particular, when proteins are readily adsorbed onto the hydrophobic or charged polymers surfaces. Therefore, the binding is extremely important in mediating various biological processes including cell adhesion and proliferation. However, it is normally difﬁcult to understand these interfacial phenomena, because the interfaces are composed of complicated interactions such as electrostatic, hydrogen bonding, or van der Waals forces. Researchers always employ vague terms such as "nonspeciﬁc" when proteins adsorb onto polymer surfaces. Phage display combinatorial libraries have been widely utilized to identify oligopeptides that speciﬁcally recognize the surfaces of artiﬁcial materials. The resulting peptides were utilized as novel functional nanomaterials. Next-generation sequencing (NGS) has emerged as a highly sensitive method for library analysis. NGS has been used to monitor from library quality control to hits discovery process, which makes it a powerful tool for better characterization of phage display libraries.

Based on our advanced phage display platform, Creative Biolabs has developed to provide various tailored biopanning strategies for the identification of synthetic polymers binding peptides with higher affinity and desired specificity.

Synthetic Polymers as Substrates for Peptide Binder Identification

PS	st-PMMA
PVC	PPV
st-PS	PDMS
α-PLLA	Epoxy resin
it-PMMA	PPyCl
mpsPPV	Azobenzene-containing poly(MA)’s

Abbreviated instructions: (PS) polystyrene; (PVC) poly(vinyl chloride); (α-PLLA) α-poly(L-lactide); (PMMA) poly(methyl methacrylate); (mpsPPV) poly(2-methoxy-5-propyloxysulfonate-1,4-phenylenevinylene); (PPV) poly(phenylene vinylene); (PDMS) poly(dimethylsiloxane); (PpyCl) chlorine-doped poly(pyrrole); (MA) methacrylate.

Applications of Synthetic Polymers Binding Peptides

Material-binding peptides for protein modification
Au nanoparticles capped with polymer-binding peptides
Modiﬁcation of polymer surfaces
Modulated ﬂuorescence of water-soluble polymers

In the field of applying phage display technology and high-throughput NGS technology, Creative Biolabs has accumulated extensive experiences. Based on our standard biopanning protocol, Creative Biolabs can tailor different strategies for synthetic polymers binding peptide identification to meet our clients’ project goals. For more detailed information, please feel free to contact us or directly send us an inquiry.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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