Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsWith years of research and development experience in the field of phage display, Creative Biolabs has a group of scientists who own the distinguished phage display technologies. Powered with various types of in-house phage display peptide libraries, Creative Biolabs is able to offer the most comprehensive services and products based on our phage display platform. Our seasoned scientists are pleased to share expertise and experience in phage selection of organic molecule binding peptides with our global clients.
The Background of Organic Molecules as Substrates of Phage Display
Small organic molecules target for phage display is more challenging than synthetic or natural polymers. In some cases, small organic molecules can be directly used as substrates for phage display in form of solid crystals. In many other cases, however, the molecules are immobilized on spherical beads or on planar substrates. Small organic molecules like fluorophores, including Texas Red, Oregon Green 514 and fluorescein, were first used as targets for phage selection. Some research groups have demonstrated the feasibility of using peptides identified by phage display for the selective detection of explosives molecules, such as 1,3,5-trinitrobenzene (TNB), 2,4-dinitrotoluene (DNT) and 2,4,6-trinitrotoluene (TNT). Besides above, phage display has also been utilized for the identification of organic molecule binding peptides for potential sensing applications or surface patterning. Octyltrimethoxysilane (OTMS) binders have been used for patterning OTMS-containing silicon surfaces via microcontact printing or photolithography. Peptides have also been identified for selective recognition of two different polychlorinated biphenyl’s (PCB’s), which are known to be carcinogenic and can accumulate in tissue.
Creative Biolabs has developed a variety of strategies to identify peptides that can selectively bind to different small organic molecules. Numbers of sub-libraries with extra mutagenesis of the identified phage clones can be constructed for further selection of clones with higher affinity than the originally selected ones.
Small Organic Molecules as Substrates for Peptide Binder Identification
| Texas Red | PCB’s |
| Oregon Green 514 | Thiamethoxam |
| Fluorescein | OTMS |
| TNT | Naphthalene |
| TNB | Trinitrotoluene |
| DNT | 2, 4-Dinitrotoluene |
For over a decade of experience in phage display technology, Creative Biolabs is dedicated to providing our customers with high-quality services. Our scientists can offer high-quality customized services in organic molecule binding peptides identification by adjusting protocols to meet every unique requirement. For more detailed information, please feel free to contact us or directly send us an inquiry.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
