Premade Antibody Library based Antibody Discovery Service for ADC Therapy

Creative Biolabs is a pioneer and undisputed global leader in the rapidly emerging market of immunotherapy. We offer a full range of premade antibody library screening services to promote the development of therapeutic antibodies, including antibody discovery for CAR-T therapy, immune checkpoint inhibitors, and ADC. We guarantee generated antibodies are well-compatible to various downstream engineering and modifications.

ADC Therapy

ADCs are monoclonal antibodies (mAbs) to which cancer drugs are attached with the help of biochemical linkers. Recently, the use of Antibody Drug Conjugates (ADCs) has emerged as a novel and effective modality in cancer therapeutics. Unlike conventional cancer drugs, ADCs target only the cancer cells. This is made possible with the help of monoclonal antibodies that bind specifically to the malignant cells. Since only the malignant cells are targeted, ADCs produce reduced side effects compared to other cancer drugs. Currently, a total of eight ADCs have been approved by the FDA and a large number of registered ADCs are in clinical trials.

Antibody Discovery for ADC Therapy from Premade Phage Displayed Antibody Library Fig.1 Structure and mechanism of action of ADC.^{1, 2}

Premade Phage Displayed Antibody Library Screening for ADC Therapy

Currently, multiple tumor proteins located on tumor cell surface have been identified as targets for ADC development. To promote the development of ADC therapy, Creative Biolabs offers antibody screening services including consultation in antigen selection, antigen-specific antibody screening, and internalizing antibody selection for global researchers. Based on advanced phage display technology, we have constructed a comprehensive portfolio of premade phage display libraries with large capacity and diversity. With rich experience and professional expertise, our scientists are dedicated to helping our clients screen novel antibodies with high antigen specificity and binding affinity. Our premade phage displayed antibody libraries include:

Libraries	Library ID	Display Technology	Library Format	Species	Library Size
Phage display human scFv libraries	HuScL-2	Phage Display	scFv	Human	1.42×10⁹
	HuScL-4	Phage Display	scFv	Human	2.0×10⁹
	HuScL-6	Phage Display	scFv	Human	1.0×10¹¹
	HuScL-7	Phage Display	scFv	Human	1.1×10¹⁰
Phage display human Fab libraries	HuFabL-4	Phage Display	Fab	Human	1.9×10¹⁰
	HuFabL-5	Phage Display	Fab	Human	1.1×10¹⁰
	HuFabssL-1	Phage Display	Fab	Human	1.8×10¹⁰

Creative Biolabs also provides antibody discovery services for different types of targets to suit a variety of applications:

Advantages of Our Service

Customized biopanning strategy with flexible antibody formats
Accurate data analysis and professional after-sale service
Extensive screening experience and comprehensive knowledge reserve
One-stop antibody discovery from antigen selection to antibody optimization

Based on unparalleled premade antibody libraries and our world-class phage display technology platform, Creative Biolabs is confident in tailoring our customers the most appropriate service to accelerate their cutting-edge projects. To learn more about how we can aid your project, please feel free to contact us.

References

Tsuchikama, K. and An, Z. Antibody-drug conjugates: recent advances in conjugation and linker chemistries. Protein & cell. 2018, 9(1), pp.33-46.
under Open Access license CC BY 4.0, without modification.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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