Creative Biolabs is one of the first-in class global manufacturers of antibodies and is professional in producing all kinds of antibodies. Based on our advanced phage display techniques and rich experiment, we have developed a full package of premade phage display libraries, which enables us to offer best-in-field phage display library screening service against specific targets. Especially, our scientists have help global researchers screened numerous antibodies for immunotherapy development, which including but not limited to immune checkpoint.
Immune checkpoints, which consist of both stimulatory and inhibitory pathways, are important immune regulators in maintaining immune homeostasis and preventing autoimmunity. Under normal circumstances, immune checkpoints allow the immune system to respond against infection and malignancy while protecting tissues from any harm that may derive from this action. However, the expression of some of these immune-checkpoint proteins by malignant cells dysregulates the antitumor immunity and favors the growth and expansion of cancer cells. Over the past decade, immune checkpoint therapy has emerged as a new pillar of cancer treatment and provides renewed hope for reducing morbidity and mortality of this complex disease. Currently, monoclonal antibodies targeting many inhibitory pathways, such as cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), programmed cell death receptor-1 (PD-1), and programmed cell death ligand-1 (PD-L1), have been developed as immune checkpoints inhibitors for cancer therapy.
At present, all the approved checkpoint inhibitors are monoclonal antibodies produced by hybridoma and engineering technology. Recently, phage display biopanning provides a high throughout tool to identify potential antibody candidates against a wide variety of molecular targets. As a leading company in the field of antibody production, Creative Biolabs has developed multiple phage displayed antibody libraries with overwhelming capacity and diversity. Our professional scientists are confident in screening impeccable antibodies with high affinity ranging from pM to nM in the formats of scFv, Fab, and sdAb. The premade phage displayed antibody libraries available at Creative Biolabs include:
Libraries | Library ID | Display Technology | Library Format | Species | Library Size |
Phage display human scFv libraries | HuScL-2 | Phage Display | scFv | Human | 1.42×109 |
HuScL-4 | Phage Display | scFv | Human | 2.0×109 | |
HuScL-6 | Phage Display | scFv | Human | 1.0×1011 | |
HuScL-7 | Phage Display | scFv | Human | 1.1×1010 | |
Phage display human Fab libraries | HuFabL-4 | Phage Display | Fab | Human | 1.9×1010 |
HuFabL-5 | Phage Display | Fab | Human | 1.1×1010 | |
HuFabssL-1 | Phage Display | Fab | Human | 1.8×1010 |
Creative Biolabs also provides antibody discovery services for different types of targets to suit a variety of applications:
Creative Biolabs is dedicated to tailoring the most suitable premade antibody library screening service according to special custom demands and expectations. For more detailed information about how we can aid your project, please feel free to contact us.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
USA:
Europe: Germany: |
|
Call us at: USA: UK: Germany: |
|
Fax:
|
|
Email: info@creative-biolabs.com |