CACNB2 Membrane Protein Introduction

Introduction of CACNB2

CACNB2, known as voltage-dependent L-type calcium channel subunit beta-2, is encoded by CACNB2 gene. It belongs to the calcium channel beta subunit family which has been deeply studied during the past few decades because it offers numerous possibilities for therapeutic applications. Recent studies show that mutations in the CACNB2 gene are associated with Brugada syndrome, autism, attention deficit-hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder, and schizophrenia.

Basic Information of CACNB2
Protein Name	Voltage-dependent L-type calcium channel subunit beta-2
Gene Name	CACNB2
Aliases	CACNLB2, MYSB
Organism	Homo sapiens (Human)
UniProt ID	Q08289
Transmembrane Times	Peripheral membrane protein
Length (aa)	660
Sequence	MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ

Function of CACNB2 Membrane Protein

CACNB2, also termed as the voltage-gated Ca_v1.2 calcium channel, can respond to membrane depolarization by increasing the membrane permeability to Ca²⁺, a major signal for cardiac muscle contraction, regulation of vascular tone and CREB-dependent transcriptional activation. CACNB2 is one of the four homologous genes coding for the auxiliary Cavβ subunits, which are important modulators of the Ca²⁺ channel activity. Studies conducted on CACNB2 suggest it can be a potential biomarker for various diseases and provide new ideas for clinical therapy. It is documented that CACNB2 is associated with Short QT syndrome (SQTS) and CACNB2 missense mutations have been identified in autism spectrum disorder (ASD) patients.

Fig.1 Structure of CACNB2 membrane protein.

Application of CACNB2 Membrane Protein in Literature

Mazzanti A., et al. The new kids on the block of arrhythmogenic disorders: Short QT syndrome and early repolarization. J Cardiovasc Electrophysiol. 2017, 28(10): 1226-1236. PubMed ID: 28569435

This article reports that the expression levels of KCNH2, KCNQ1, KCNJ2, CACNA1C, and CACNB2 are associated with Short QT syndrome (SQTS). Authors summarize the latest literature on SQTS and ERS, and illustrate the key steps that first lead to the identification of the syndrome, including the epidemiology, genetics, diagnosis, clinical manifestations, and management.
Amare A.T., et al. The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies. Transl Psychiatry. 2017, 7(1): e1007. PubMed ID: 28117839

This article conducts genome-wide association studies and analyzes candidate gene studies which are associated with cardiovascular diseases, metabolic diseases, and mood disorders. These results reveal that the shared biological mechanisms of mood disorders and cardiometabolic diseases.
Soldatov N.M., et al. CACNB2: An Emerging Pharmacological Target for Hypertension, Heart Failure, Arrhythmia, and Mental Disorders. Curr Mol Pharmacol. 2015, 8(1): 32-42. PubMed ID: 25966706

Authors in this group reveal the function of Cavβ2-specific molecular in various diseases. The results indicate it could be an emerging pharmacological target for hypertension, heart failure, arrhythmia, and mental disorders.
Breitenkamp A.F., et al. Rare mutations of CACNB2 found in autism spectrum disease-affected families alter calcium channel function. PLoS One. 2014, 9(4): e95579. PubMed ID: 24752249

This article focuses on three rare CACNB2 missense mutations identified in ASD patients. The data suggest the mutations be of physiological relevance since they modulate whole-cell Ca²⁺ currents through calcium channels when expressed in a recombinant system (HEK-293 cells).
Kim Y.S., et al. Recent challenges to the psychiatric diagnostic nosology: a focus on the genetics and genomics of neurodevelopmental disorders. Int J Epidemiol. 2014, 43(2): 465-75. PubMed ID: 24618187

This article evaluates the expression level of ITIH3, AS3MT, CACNA1C and CACNB2 genes, and these results show that rare mutations of these genes play an important role in providing important new insights into the genetics and diagnosis of neurodevelopmental disorder (NDD).

CACNB2 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-CACNB2 antibody development services.

As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.

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