Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsVoltage-dependent calcium channels (VDCCs), also termed as voltage-gated calcium channels (VGCCs), are a family of multimeric transmembrane proteins present in the membrane of excitable cells. VDCCs are characterized by a permeability to the Ca2+ and involved in calcium homeostasis, gene expression, and neurotransmitter release. VDCCs are key transducers of membrane potential changes into intracellular Ca2+ transients that initiates many physiological events. Ten members of the voltage-gated Ca2+ channel family are present in mammals and play distinct roles in cellular signal transduction. VDCCs are multi-subunit complexes, which consist of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio.
Here, we present part of VDCCs protein in humans including the CaV1 subfamily, CaV2 subfamily, and the CaV3 subfamily. The CaV1 subfamily initiates contraction, secretion, regulation of gene expression, integration of synaptic input in neurons, and synaptic transmission at ribbon synapses in specialized sensory cells. The CaV2 subfamily is primarily responsible for initiation of synaptic transmission at fast synapses. The CaV3 subfamily plays an important role in the repetitive firing of action potentials in rhythmically firing cells such as cardiac myocytes and thalamic neurons.
| Human Voltage-dependent Calcium Channel Family Members | ||||
| CACNA1A | CACNA1B | CACNA1C | CACNA1D | CACNA1E |
| CACNA1F | CACNA1G | CACNA1H | CACNA1I | CACNA1S |
| CACNA2D1 | CACNA2D2 | CACNA2D3 | CACNA2D4 | CACNB1 |
| CACNB2 | CACNB3 | CACNB4 | CACNG2 | CACNG4 |
| CACNG5 | CACNG6 | CACNG7 | CACNG8 | |
Based on cutting-edge Magic™ membrane protein production platform, Creative Biolabs is pleased to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Moreover, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, applied various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
