CACNB4 Membrane Protein Introduction

Introduction of CACNB4

CACNB4, known as voltage-dependent L-type calcium channel subunit beta-4, is encoded by the CACNB4 gene. CACNB4 belongs to the calcium channel beta subunit family which has been extensively studied during the past few years because it has numerous possibilities for therapeutic applications. Recent studies reveal that CACNB4 mutations may be associated with a lot of diseases, such as epilepsy, idiopathic dilated cardiomyopathy and episodic ataxia.

Basic Information of CACNB4
Protein Name	Voltage-dependent L-type calcium channel subunit beta-4
Gene Name	CACNB4
Aliases	CACNLB4
Organism	Homo sapiens (Human)
UniProt ID	O00305
Transmembrane Times	Peripheral membrane protein
Length (aa)	520
Sequence	MSSSSYAKNGTADGPHSPTSQVARGTTTRRSRLKRSDGSTTSTSFILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPMTPLLGRNLGSTALSPYPTAISGLQSQRMRHSNHSTENSPIERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGYSHDSRHRL

Function of CACNB4 Membrane Protein

The CACNB4 gene encodes a calcium channel subunit expressed in the heart that is important for cardiac muscle contraction. It plays a role in the regulation of cell proliferation and cell cycle progression. Studies conducted on CACNB4 suggest mutations of the neuronal Cacnb4 (β₄) subunit are linked to human neuropsychiatric disorders including epilepsy and intellectual disabilities. It can be a potential biomarker for various diseases and provide new ideas for clinical therapy. It is documented that coexpression of CACNB4 with actors of the canonical Wnt/β-catenin signaling pathway in a hepatoma cell line can inhibit Wnt-responsive gene transcription and decreases cell division, in agreement with the role of the Wnt pathway in cell proliferation.

Fig.1 Structure of CACNB4 membrane protein.

Application of CACNB4 Membrane Protein in Literature

Xu H., et al. A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans. J Pers Med. 2018, 26: 8(1). PubMed ID: 29495422

This article conducts a Genome-wide Association Study to identify susceptibility genes for idiopathic dilated cardiomyopathy in African Americans. These results show that an SNP of CACNB4 gene is significantly associated with IDC.
Choi K.D., et al. Genetic Variants Associated with Episodic Ataxia in Korea. Sci Rep. 2017, 23: 7(1), 13855. PubMed ID: 29062094

This article conducts a Whole genome sequencing (WGS) on 39 Korean patients with episodic ataxia (EA) to identify pathogenic mutations of the five known EA genes. The result shows that KCNA1, CACNA1A, CACNB4, SLC1A3, and UBR4 can be targeted for EA diagnoses.
Rima M., et al. Down-regulation of the Wnt/β-catenin signaling pathway by Cacnb4. Mol Biol Cell. 2017, 28(25): 3699-3708. PubMed ID: 29021340

Authors in this group analyze the function and transcription of the β₄-subunit in a hepatoma cell line inhibits Wnt-responsive gene. The data show that β₄-subunit is a TCF4 repressor and therefore appears as an interesting candidate for the regulation of Wnt/β-catenin signaling pathway in neurons where β₄-subunit is specifically expressed.
Rima M., et al. The β₄ subunit of the voltage-gated calcium channel (Cacnb4) regulates the rate of cell proliferation in Chinese Hamster Ovary cells. Int J Biochem Cell Biol. 2017, 89: 57-70. PubMed ID: 28587927

This article evaluates the role of β₄ subunit in cell proliferation and cell cycle progression and examines whether these functions could be altered by a pathogenic mutation. These results indicate that mutations of the β₄ subunit could affect neural development and formation of the mature central nervous system.
Chu H., et al. Integrated network analysis reveals potentially novel molecular mechanisms and therapeutic targets of refractory epilepsies. PLoS One. 2017, 12(4): e0174964. PubMed ID: 28388656

This article examines the relationship between current drug targets and the epilepsy-related disease genes. The data reveal ten potential novel drug targets, include CACNB4, for RE therapy.

CACNB4 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-CACNB4 antibody development services.

As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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