Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsIntroduction of CACNG2
CACNG2 is encoded by CACNG2 gene. It belongs to the neuronal calcium channel gamma subunit subfamily which has been extensively studied during the past few decades because it offers numerous possibilities for therapeutic applications. It is one of the five subunits of L-type calcium channels. Recent studies show that CACNG2 has been used as a novel neuropathic pain gene affecting pain susceptibility both in mice and humans.
| Basic Information of CACNG2 | |
| Protein Name | Voltage-dependent calcium channel gamma-2 subunit |
| Gene Name | CACNG2 |
| Aliases | MRD10 |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q9Y698 |
| Transmembrane Times | 4 |
| Length (aa) | 323 |
| Sequence | MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKENKDSLHSNTANRRTTPV |
Function of CACNG2 Membrane Protein
CACNG2 is a type I transmembrane AMPA receptor regulatory protein (TARP). It can be expressed in the brain and plays an important role in biological functions, such as synaptic plasticity, learning, and memory. CACNG2 can change the biophysical properties of AMPA receptors in remarkable ways and thus contribute significantly to the functional plasticity of the synapse. Previous research indicates the mouse gamma2 gene (Cacng2) is related with the stargazer mutant mouse line. It can downregulate calcium channel activity by causing a hyperpolarizing shift in the inactivation curve. It is reported that CACNG2 is related to the perception of pain.
Fig.1 Structure of the AMPA receptor.
Application of CACNG2 Membrane Protein in Literature
This article summarizes the related genes on mood disorders and tries to identify the biomarkers. These results show that several SNPs located at candidate genes that possibly influence response to the treatment on mood disorders, which could be useful for clinical therapy.
This article reveals that the effect of reduced Cacng2a and 2b levels on synaptic physiology on Zebrafish Mauthner cells. The result shows that Cacng2a is required for normal trafficking and function of synaptic AMPARs, while Cacng2b is largely non-functional with respect to the development of AMPA synaptic transmission.
Authors in this group summarize a synthesis of literature data about the influence of genetic factors on pain perception and its treatment. The data indicate that some genes, including CACNG2, are related to the perception of pain.
CACNG2 Preparation Options
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-CACNG2 antibody development services.
As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
