CACNG6 Membrane Protein Introduction

Introduction of CACNG6

Voltage-gated calcium channels (VGCC) are a group of voltage-gated ion channels, also known as voltage-dependent calcium channels (VDCC), present in membranes of excitable cells (such as muscle, glial cells, neurons, etc.). It is a permeable calcium ion Ca²⁺ channel. The voltage-gated channel that exists in the neuron is also called Voltage-dependent calcium channel. The voltage-dependent calcium channel gamma-6 subunit (CACNG6) is an integral membrane protein encoded by gene CACNG6. The calcium channel gamma subunits comprise an eight-member protein family. CACNG6 protein is a member of voltage-dependent calcium channel gamma subunits and usually has a role in stabilizing calcium channels.

Basic Information of CACNG6
Protein Name	Voltage-dependent calcium channel gamma-6 subunit
Gene Name	CACNG6
Aliases	Neuronal voltage-gated calcium channel gamma-6 subunit
Organism	Homo sapiens (Human)
UniProt ID	Q9BXT2
Transmembrane Times	4
Length (aa)	260
Sequence	MMWSNFFLQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTEFWVELNTYKANGSAVCEAAHLGLWKACTKRLWQADVPVDRDTCGPAELPGEANCTYFKFFTTGENARIFQRTTKKEVNLAAAVIAVLGLAVMALGCLCIIMVLSKGAEFLLRVGAVCFGLSGLLLLVSLEVFRHSVRALLQRVSPEPPPAPRLTYEYSWSLGCGVGAGLILLLGAGCFLLLTLPSWPWGSLCPKRGHRAT

Function of CACNG6 Membrane Protein

CACNG6 is a subunit of the calcium channel gamma subunits, and the calcium channel gamma subunits are part of voltage-gated L-type calcium channels (VLCCs). VLCCs are a group of voltage-gated ion channels found in the membrane of excitable cells. CACNG6 can regulate the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. The CACNG6 gene is part of a versatile octaprotein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster of two family members that functions as a transmembrane AMPA receptor regulatory protein (TARP). Alternative splicing results in the production of multiple transcript variants. Variations in the CACNG6 gene are associated with asthma that is intolerant to aspirin.

Fig.1 The role of CACNG6 in skeletal muscle development. (Amy, 2017)

Application of CACNG6 Membrane Protein in Literature

Lee J.S., et al. Association of CACNG6 polymorphisms with aspirin-intolerance asthmatics in a Korean population. BMC Med Genet. 2010, 11(1): 138. PubMed ID: 20860846

This article reports that the expression of the CACNG6 gene has a negative association with chronic obstructive pulmonary disease, and its variation may be related to the occurrence of AIA in the Korean population.
Guan F., et al. Evaluation of voltage-dependent calcium channel γ gene families identified several novel potential susceptible genes to schizophrenia. Scientific Reports. 2016, 6: 24914. PubMed ID: 27102562

This article reveals that there are many voltage-gated L-type calcium channels (VLCC) in the brain, and genes involved in schizophrenia (SCZ), which encode VLCC subunits, play a role, we have indicated that CACNG6 may cause SCZ risk.
Burgess D.L., et al. A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family. Genomics. 2001, 71(3): 339-50. PubMed ID: 11170751

This article reveals that CACNG6, CACNG7, and CACNG8, are located in a tandem array on 19q13.4 and are homologous to CACNG1, CACNG5 and CACNG4.

CACNG6 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-CACNG6 antibody development services.

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Reference

Amy E Brinegar, et al. (2017). Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions. eLife.

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