All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
Creative Biolabs has developed a switchable CAR (sCAR) T cell platform that allows dose-titratable control over CAR T cell activity by using adaptor-based switches. Our switchable CAR product aims to further evolve CAR-T cell therapy based on combinations of so-called universal or modular CAR-(uniCAR/modCAR-) T cells, and their respective adaptor molecules (CAR-adaptors), which mediate the crosslinking between target and effector cells. Thus, the universal or modCARs describe chimeric receptors that do not directly recognize the target antigen, but instead make contact to adaptor molecules (CAR-adaptors), that in turn bind to the target antigen. Contrary to conventional CAR-T cells, where the immunological synapse is established by direct interaction of CAR and membrane-bound target, modCAR-T cells provide a highly flexible and customizable development of the CAR-T cell concept and offer an additional possibility to control T cell activity.
There are currently no customer reviews or questions for A uniCAR [Anti-FITC CAR], with a mAb-based CAR Adaptor [Anti-EGFR (Cetuximab)], a Switchable CAR System (CAR-ZP8476). Click the button below to contact us or submit your feedback about this product.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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