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The archetypal AS01 TCR is likely to be one of the most common and numerically frequent αβ TCRs in humans. This is based on the following considerations: (i) the HLA-A*0201 allele is arguably the most common and widespread MHC-I allele in humans, with frequencies above 60% in certain regions; (ii) EBV is one of the most successfully disseminated human pathogens, persistently infecting more than 90% of individuals; (iii) the GLC-A2 antigen is one of the most immunodominant CD8+ T cell targets across the EBV proteome; (iv) GLC-specific CD8+ T cell responses are amongst the largest observed, both in the EBV system and in comparative terms with respect to other human pathogens studied thus far; and, (v) the GLC-specific response is dominated by CD8+ T cells that bear a public TRAV5/TRBV20-1 receptor.
There are currently no customer reviews or questions for Human anti-BSLF2/BMLF1 T cell receptor (AS01), pCDTCR1 (TCR-YC0141). Click the button below to contact us or submit your feedback about this product.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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