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The vector of anti-CD123 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CD123. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD123 antibody linked to CD4 transmembrane domain and FcεRIγ signaling domains. And the vector product was designed for the treatment of acute myeloid leukaemia (AML).
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CAR Construction :
Fig.1 Binding characteristics of anti-CD123 clone 7G3. FCM binding analysis of anti-CD123 clones (11F11, 10C4, 7G3, 5G4, 1H8; used at 2 µg/mL) against parental RS4;11 cells (endogenously lacking CD123), RS4;11 cells transduced with human CD123, CD123-expressing human AML cells lines (TF-1, KG-1, MOLM-13), and MOLM-13 cells (CD123KO). Laszlo, G. S., Orozco, J. J., Kehret, A. R., Lunn, M. C., Huo, J., Hamlin, D. K., ... & Walter, R. B. (2022). Development of [211At] astatine-based anti-CD123 radioimmunotherapy for acute leukemias and other CD123+ malignancies. Leukemia, 36(6), 1485-1491. |
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