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Anti-HLA-A T cell receptor (CBY1), pCDTCR1 (TCR-YF002)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-HLA-A T cell receptor (TCR) is constructed for the engineering of T cell to target HLA-A. The T cells are genetically modified through transduction with a lentiviral vector expressing HLA-A-specific T cell receptor. And the vector product was designed for the treatment of Others.

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Details

  • Target
  • HLA-A
  • Target Species
  • Human
  • Epitope
  • RYLENGKETL
  • Format
  • Non-modified
  • Allele
  • H2-Kd
  • Targeting Diseases
  • Others
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • CBY1
  • Host Species
  • Mouse

Target

  • Introduction
  • HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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