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Anti-LCP1 T cell receptor, pCDTCR1 (TCR-ZP616)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-LCP1 T cell receptor (TCR) is constructed for the engineering of T cell to target Human. The T cells are genetically modified through transduction with a lentiviral vector expressing LCP1-specific T cell receptor. And the vector product was designed for the treatment of Breast cancer.

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Details

  • Target
  • LCP1
  • Target Species
  • Human
  • Epitope
  • NLFNRYPAL
  • Format
  • Non-modified
  • Allele
  • HLA class I
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Breast cancer
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • LC2
  • Host Species
  • Human

Target

  • Introduction
  • Plastins are a family of actin binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L plastin has been found in many types of malignant human cells of non hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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