Anti-MDM2 DNA-encoded mAb (DMAb), pVAX1 (DMAb-2112-FY)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-MDM2 DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
MDM2

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
4193

UniProt ID
Q00987

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-2112-FY	CBFYM-0323	Mouse	Human	IgG2a	Synthetic peptide, conjugated to KLH, corresponding to residues 389-402 of human MDM2
DMAb-2113-FY	CBFYM-0419	Mouse	Human	IgG1
DMAb-2114-FY	CBFYM-0613	Mouse	Human
DMAb-2115-FY	CBFYM-1955	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 119-438 of human MDM2 (NP_002383) produced in E.coli
DMAb-2116-FY	CBFYM-1956	Mouse	Human	IgG2a	Synthetic peptide conjugated to KLH, corresponding to amino acids 389-402 of Human MDM2. Epitope: The epitope recognized by the antibody is localized in the C-terminal region of MDM2 (amino acids 389-402 of human MDM2)
DMAb-2117-FY	CBFYM-1957	Mouse	Human	IgG2b	E. coli-derived recombinant human MDM2/HDM2, Asn3-Pro491
DMAb-2118-FY	CBFYM-1958	Mouse	Human	IgG2a	Synthesized peptide of human MDM2 (AA: ASEQETLVRPKPLLc)
DMAb-2119-FY	CBFYM-1959	Mouse	Human	IgG2b, k	A synthetic peptide derived from human MDM2 protein (1)
DMAb-2120-FY	CBFYM-1960	Mouse	Human	IgG1, k	Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
DMAb-2121-FY	CBFYM-1961	Mouse	Human	IgG2b, k	Synthetic peptide corresponding to the N-terminal of human MDM2
DMAb-2122-FY	CBFYM-1962	Mouse	Human	IgG1	Synthetic peptide, CSRPSTSSRRRAISE, corresponding to amino acids 154-167 of human MDM2
DMAb-2123-FY	CBFYM-1963	Rabbit	Human	IgG	Recombinant protein corresponding to amino acids 215-422 of human MDM2
DMAb-2124-FY	CBFYM-1964	Mouse	Human	IgG1	KLH conjugated synthetic peptide encompassing a sequence within the N-term region of human MDM2
DMAb-2125-FY	CBFYM-1965	Mouse	Mouse	IgG1	Recombinant mouse MDM2

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-MDM2 DNA-encoded mAb (DMAb), pVAX1 (DMAb-2112-FY)

Specifications

Target

Customer Reviews and Q&As

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