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This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-WFY2112 | Anti-MDM2 (CBFYM-0323) h(41BB-CD3ζ) CAR, pCDCAR1 | Human, Mouse | CBFYM-0323 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY2113 | Anti-MDM2 (CBFYM-0419) h(41BB-CD3ζ) CAR, pCDCAR1 | Mouse, Rat, Human | CBFYM-0419 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY2114 | Anti-MDM2 (CBFYM-0613) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYM-0613 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY2115 | Anti-MDM2 (CBFYM-1955) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYM-1955 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY2116 | Anti-MDM2 (CBFYM-1956) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYM-1956 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY2117 | Anti-MDM2 (CBFYM-1957) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYM-1957 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY2118 | Anti-MDM2 (CBFYM-1958) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYM-1958 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY2119 | Anti-MDM2 (CBFYM-1959) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYM-1959 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY2120 | Anti-MDM2 (CBFYM-1960) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYM-1960 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY2121 | Anti-MDM2 (CBFYM-1961) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYM-1961 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY2122 | Anti-MDM2 (CBFYM-1962) h(41BB-CD3ζ) CAR, pCDCAR1 | Human, Mouse | CBFYM-1962 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY2123 | Anti-MDM2 (CBFYM-1963) h(41BB-CD3ζ) CAR, pCDCAR1 | Human, Mouse | CBFYM-1963 | Rabbit | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY2124 | Anti-MDM2 (CBFYM-1964) h(41BB-CD3ζ) CAR, pCDCAR1 | Human, Mouse, Rat | CBFYM-1964 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY2125 | Anti-MDM2 (CBFYM-1965) h(41BB-CD3ζ) CAR, pCDCAR1 | Mouse | CBFYM-1965 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY5371 | Anti-MDM2 (CBFYM-1958) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | CBFYM-1958 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY5372 | Anti-MDM2 (CBFYM-1959) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | CBFYM-1959 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY5373 | Anti-MDM2 (CBFYM-1960) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | CBFYM-1960 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY5374 | Anti-MDM2 (CBFYM-1961) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | CBFYM-1961 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY5375 | Anti-MDM2 (CBFYM-1962) h(CD28-CD3ζ) CAR, pCDCAR1 | Human, Mouse | CBFYM-1962 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY5376 | Anti-MDM2 (CBFYM-1963) h(CD28-CD3ζ) CAR, pCDCAR1 | Human, Mouse | CBFYM-1963 | Rabbit | scFv-CD28-CD3ζ | Lentiviral vector | T cell |
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CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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