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The 506β mice infected with Vac:IAb–3K expanded a large population of IFNγ-producing CD4 T cells that recognized the 3K variant ligands, P-1L and P-1K. In contrast, Vac:3K–GFP expanded CD4 T cells with these cross-reactivities very poorly. An increased precursor frequency of CD4 T cells in 506β mice for 3K and the 3K APLs may allow these lower potency, P-1L and P-1K cross-reactive CD4 T cells to be expanded following Vac:IAb–3K infections, whereas in a completely polyclonal population these cells would fail to be activated because of some aspect of T-cell competition.
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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