Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
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EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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Recombinant Moloney murine leukemia virus (MMLV) retroviral vectors serve as efficient viral vector tools for introducing genes permanently into a wide variety of dividing cells, and provide an alternative to modify primary T cells. Creative biolabs has developed retroviral CAR vector pMMLV PMEL (77E6) h(BBζ), which is constructed for the engineering of T cells to target human PMEL. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-PMEL antibody linked to CD137 (4-1BB) and CD3-zeta signaling domains. And the vector product was designed for the treatment of Pigmentary diseases.
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CAR Construction :
Fig.1 Binding of PMEL17 antibodies to intact cells. Fluorescence-activated cell sorting of mel928 cells stained with antibodies 17A9 and 77E6. Chen, Y., Chalouni, C., Tan, C., Clark, R., Venook, R., Ohri, R., ... & Polakis, P. (2012). The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma. Journal of Biological Chemistry, 287(29), 24082-24091. |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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