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CerS5 robustly synthesizes C16-ceramide, which is often considered to be an important pro-apoptotic ceramide. De novo ceramide synthesis is an essential trigger for Bax activation in hypoxia/reoxygenation. Following hypoxia/reoxygenation, CerS5 expression is elevated. Upon knocking down acid sphingomyelinase and CerS5 in NTERA-2cells, Bax localization to mitochondria was reduced, indicating the importance of CerS5 activity in the apoptosis pathway.
CAT | Product Name | Target Species | TCR Clone | Host Species | Epitope | Allele | Vector Type | Inquiry & Datasheet |
TCR-C253Z | Mouse anti-Trh4 T cell receptor (LnB5), pCDTCR1 | Mouse | LnB5 | Mouse | MCLRMTAVM | H-2Db | Lentiviral |
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