Complement Factor I Blocking Peptide-2(Cat#: CTD-092)
This product is a synthetic peptide that used for blocking the activity of human Complement Factor I antibody.
Summary
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Specifications
| Sequence |
AGTYDGSIDA CKGDSGGPLV CMDANNVTYV WGVVSWGENC GKPEFPGVYT |
| Purity |
>90% |
| Pack Size |
100 μg |
| Format |
Lyophilized |
| Conjugate |
Unconjugated |
| Species Reactivity |
Human |
| Applications |
Blocking; WB |
| Storage |
Short at 4°C for short term and at -20°C for long term. |
Information
| Introduction |
Complement factor I is a Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
