Human CD11b ELISA Kit-CTK-678(Cat#: CTK-678)
This product is an ELISA kit for the determination of Human CD11b in the samples of Plasma, Serum, Tissue Homogenate. It is highly sensitive and available for the detection of Human CD11b as low as 12.9 pg/mL.
Summary
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Specifications
| Assay Type |
Sandwich ELISA |
| Sensitivity |
12.9 pg/mL (31.2-2000 pg/mL) |
| Pack Size |
96 tests |
| Species Reactivity |
Human |
| Target |
CD11b |
| Cross Reactivity |
No significant cross-reactions have been observed between Human CD11b and analogues, but existing techniques may limit the detection of cross-reactions with untested analogues. |
| Applications |
ELISA |
| Storage |
4°C |
Information
| Introduction |
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
