Mouse Anti-Human CD18 Monoclonal Antibody (CTJS-194) [iFluor® 405](Cat#: CTA-897)
This product is a conjugated anti-Human CD18 Monoclonal antibody (CTJS-194) generated from the Mouse. The antibody can be used for IF, IHC, FC.
Summary
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Specifications
| Clonality |
Monoclonal |
| Clone |
CTJS-194 |
| Host Animal |
Mouse |
| Isotype |
IgG2a κ |
| Immunogen |
The full length of human Integrin β2, a.a. 1-769 |
| Species Reactivity |
Human |
| Applications |
IF; IHC; FC |
| Application Notes |
IF: 1:50-1:500
IHC: 1:50-1:500
FC: 1 µg/10^6 cells
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody reacts with Human CD18. |
| Purity |
≥95% as determined by SDS-PAGE |
| Conjugation |
iFluor® 405 |
| Format |
Liquid |
| Size |
100 µg |
| Storage |
Store in dark at 4°C. Do Not Freeze. |
| Type |
Primary Antibody |
Target
| Target Name |
CD18 |
| Alternative Names |
Integrin Subunit Beta 2; Integrin, Beta 2 (Complement Component 3 Receptor 3 And 4 Subunit); Complement Component 3 Receptor 3 And 4 Subunit; Integrin Beta-2; LFA-1; MAC-1; CD18; Complement Receptor C3 Beta-Subunit; Complement Receptor C3 Subunit Beta; Integrin Beta Chain, Beta 2; CD18 Antigen; ITGB2 |
| Gene ID |
3689 |
| UniProt ID |
P05107 |
Information
| Introduction |
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
