Mouse CD46 ELISA Kit(Cat#: CTK-690)
This product is an ELISA kit for the determination of Mouse CD46 in the samples of Serum, Plasma, Tissue Homogenate. It is highly sensitive and available for the detection of Mouse CD46 as low as 0.78 ng/mL.
Summary
Related Products & Services
Specifications
| Assay Type |
Sandwich ELISA |
| Sensitivity |
0.78 ng/mL |
| Pack Size |
96 tests |
| Species Reactivity |
Mouse |
| Target |
CD46 |
| Cross Reactivity |
No significant cross-reactions have been observed between Mouse CD46 and analogues, but existing techniques may limit the detection of cross-reactions with untested analogues. |
| Applications |
ELISA |
| Storage |
Short-term storage at 4°C and long-term storage at -20°C. |
Information
| Introduction |
Membrane cofactor protein acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. In microbial infection, a number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. It also acts as a receptor for Adenovirus subgroup B2 and Ad3, a receptor for cultured Measles virus, a receptor for Herpesvirus 6/HHV-6, and a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
