This product is an ELISA kit for the determination of Mouse CD59a in the samples of Plasma and Serum. It is highly sensitive and available for the detection of Mouse CD59a as low as 25.5 pg/mL.
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Assay Type | Sandwich ELISA |
Sensitivity | 25.5 pg/mL (62.50-4000 pg/mL) |
Pack Size | 96 tests |
Species Reactivity | Mouse |
Target | CD59a |
Cross Reactivity | No significant cross-reactions have been observed between Mouse CD59a and analogues, but existing techniques may limit the detection of cross-reactions with untested analogues. |
Applications | ELISA |
Storage | The storage of components varies. Please refer to the instructions for details. |
Introduction | CD59 glycoprotein is a potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. |