Rabbit Anti-Human Clusterin Polyclonal Antibody(Cat#: CTA-423)

Name: Rabbit Anti-Human Clusterin Polyclonal Antibody
SKU: CTA-423
Rating: 5 (1 reviews)

This product is an unconjugated anti-Human Clusterin Polyclonal antibody generated from the Rabbit. The antibody can be used for IHC.

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Specifications

Clonality	Polyclonal
Host Animal	Rabbit
Isotype	IgG
Immunogen	This antibody was developed against Recombinant Protein corresponding to amino acids: SSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNS
Species Reactivity	Human
Applications	IHC
Application Notes	IHC: 1:200 - 1:500 The optimal working dilutions should be determined by the end user.
Specificity	This antibody reacts with Human Clusterin.
Purity	≥95% as determined by SDS-PAGE
Format	Liquid
Size	25; 100 µL
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Type	Primary Antibody

Target

Target Name	Clusterin
Alternative Names	Testosterone-Repressed Prostate Message;Clusterin (Complement Lysis Inhibitor, SP-40,40, Sulfated Glycoprotein 2, Testosterone-Repressed Prostate Message 2, Apolipoprotein J); ; Apolipoprotein J; Complement-Associated Protein SP-40,40; Complement Cytolysis Inhibitor; Complement Lysis Inhibitor; Sulfated Glycoprotein 2; Ku70-Binding Protein 1; NA1/NA2; TRPM-2; APOJ; KUB1; CLI; Aging-Associated Gene 4 Protein; Aging-Associated Protein 4; APO-J; SGP-2; SP-40; TRPM2; Apo-J; AAG4; CLU1; CLU2; SGP2
Gene ID	1191
UniProt ID	P10909

Information

Introduction

Clusterin (apolipoprotein J) is a 75 - 80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis. In humans, clusterin is encoded by the CLU gene on chromosome 8. CLU is a molecular chaperone responsible for aiding protein folding of secreted proteins, and its three isoforms have been differentially implicated in pro- or antiapoptotic processes. Through this function, CLU is involved in many diseases related to oxidative stress, including neurodegenerative diseases, cancers, inflammatory diseases, and aging. CLU is a member of the small heat shock protein family and, thus, a molecular chaperone. Unlike most other chaperone proteins, which aid intracellular proteins, CLU is a Golgi chaperone that facilitates the folding of secreted proteins in an ATP-independent way.

For Research Use Only. Not for Diagnostic or Therapeutic Applications.