This product is an ELISA kit for the determination of Rat Complement C5a in the samples of serum, plasma and other biological fluids. It is highly sensitive and available for the detection of Rat Complement C5a as low as 0.39 ng/mL.
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Assay Type | Sandwich ELISA |
Sensitivity | 0.39 ng/mL (1.56-100 ng/mL) |
Pack Size | 96 tests |
Species Reactivity | Rat |
Target | C5a |
Cross Reactivity | No significant cross-reactions have been observed between Rat Complement C5a and analogues, but existing techniques may limit the detection of cross-reactions with untested analogues. |
Applications | ELISA |
Storage | The storage of components varies. Please refer to the instructions for details. |
Introduction | Complement C5a is the alpha chain released from cleavage of complement C5 protein, which plays an important role in chemotaxis. C5a is an effective chemoattractant, initiating accumulation of complement and phagocytic cells at sites of infection or recruitment of antigen-presenting cells to lymph nodes. C5a plays a key role in increasing migration and adherence of neutrophils and monocytes to vessel walls. White blood cells are activated by upregulation of integrin avidity, the lipoxygenase pathway and arachidonic acid metabolism. C5a also modulates the balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing the autoimmune response. |