This product is a recombinant human C4BPB protein with a N-terminal tag or C-terminal tag expressed in the E. Coli, yeast, insect, or mammalian cell. It is available for WB, ELISA.
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Expressed Host | E. Coli, yeast, insect, or mammalian cell |
Specie Reactivity | Human |
Target | C4BPB |
Purity | >85% as determined by SDS-PAGE |
Endotoxin | <1.0EU per 1µg (determined by the LAL method) |
Formulation | Tris-based buffer, 50% glycerol |
Applications | WB; ELISA |
Product Form | Liquid/Lyophilized |
Storage | Store working aliquots at 4°C for up to one week. The shelf life of liquid form is 6 months at -20C/-80°C. The shelf life of lyophilized form is 12 months at -20C/-80°C. Avoid repeated freezing and thawing. |
Introduction | C4b-binding protein beta chain controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S. |
Alternative Names | C4b binding protein beta chain; C4b-binding protein beta chain, C4BP; Complement component 4 binding protein, beta chain; Complement component 4-binding protein, beta |
Gene ID | 725 |
UniProt ID | P20851 |