Recombinant Human Complement C5aR2 Protein-His6-ABP tag(Cat#: CTP-249)
This product is a 21 kDa recombinant human complement C5aR2 protein with a His6-ABP tag at N-terminal expressed in the E.coli. It is available for Antibody Competition.
Summary
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Specifications
| Expressed Host |
E. Coli |
| Specie Reactivity |
Human |
| Target |
C5aR2 |
| Molecule Mass |
21 kDa |
| Purity |
>80% determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
PBS and 1M Urea, pH 7.4 |
| Applications |
AC |
| Product Form |
Liquid |
| Storage |
Store at -20°C. Avoid freeze-thaw cycles. |
Protein Information
| Introduction |
C5a anaphylatoxin chemotactic receptor 2 (C5AR2) is a receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. Complement fragment C5a is a 74-residu glycopolypeptide which is generated by proteolytic cleavage of the complement factor C5 in the course of complement activation. C5a is a potent chemoattractant and anaphylatoxin that acts on all classes of leukocytes and on many other cell types including endothelial, smooth muscle, kidney, liver, and neural cells. In addition to its proinflammatory effects, C5a has been shown to protect cells against toxic insult and to stimulate proliferation in neurons and hepatocytes, suggesting a wider role for C5a in homeostasis. |
| Alternative Names |
Complement component 5a receptor 2; G-protein coupled receptor 77; C5AR2; C5L2; GPR77 |
| Gene ID |
27202 |
| UniProt ID |
Q9P296 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
