Recombinant Human Complement Factor I-His and GST Tag(Cat#: CTP-245)
This product is a 56.7 kDa recombinant human Complement Factor I protein with N-terminal His and GST Tag expressed in the E.coli. It is available for Positive Control, Immunogen, SDS-PAGE, WB.
Summary
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Specifications
| Expressed Host |
E. Coli |
| Specie Reactivity |
Human |
| Target |
Factor I |
| Molecule Mass |
56.7 kDa |
| Purity |
> 95% determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300 |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Product Form |
Liquid |
| Storage |
Store at 2-8°C for short time. Aliquot and store at -80°C for 12 months. Avoid repeated freeze/thaw cycles. |
Protein Information
| Introduction |
Complement factor I (CFI), also known as C3b/C4b inactivator, is a glycosylated protein in the complement system that encoded by the human CFI gene. Acting as plasma trypsin-like serine proteinase, CFI was first identified in 1966 as an enzyme involved in the physiological degradation of C3, a major plasma complement protein. CFI is a heterodimer consisting of a disulfide-linked heavy chain and light chain, which plays an essential role in regulating the immune response by controlling all complement pathways. It inhibits activations of all three complement pathways by cleaving and inactivating C4b and C3b to regulate the levels of C3 and C5 convertases. The diseases associated with CFI include Complement Factor I Deficiency, Recurrent Infections, Atypical Hemolytic Uremic Syndrome, and Macular Degeneration Age-Related 13. |
| Alternative Names |
Konglutinogen-Activating Factor; C3B/C4B Inactivator; C3b-Inactivator; Complement Control Protein Factor I; Complement Factor I Heavy Chain; Light Chain Of Factor I; Complement Component I; I Factor (Complement); EC 3.4.21.45; FI; IF; KAF; AHUS3; ARMD13; C3BINA; C3b-INA |
| Gene ID |
3426 |
| UniProt ID |
P05156 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
