Recombinant Mouse CD46 Protein-N-terminal His Tag(Cat#: CTP-334)
This product is a recombinant mouse CD46 protein with a N-terminal His Tag tag expressed in the E.coli. It is availible for WB, ELISA, IA.
Summary
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Specifications
| Expressed Host |
E.coli |
| Specie Reactivity |
Mouse |
| Target |
CD46 |
| Purity |
>90 % determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
20 mM Tris-HCl based buffer, pH 8.0 |
| Applications |
WB; ELISA; IA |
| Product Form |
Liquid |
| Storage |
Store at -20°C/-80°C. Avoid freeze-thaw cycles. |
Protein Information
| Introduction |
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.
Acts as a receptor for Adenovirus subgroup B2 and Ad3.
Acts as a receptor for cultured Measles virus.
Acts as a receptor for Herpesvirus 6/HHV-6.
May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes. |
| Alternative Names |
CD46 Molecule; Membrane Cofactor Protein (CD46, Trophoblast-Lymphocyte Cross-Reactive Antigen); Antigen Identified By Monoclonal Antibody TRA-2-10; CD46 Molecule, Complement Regulatory Protein; CD46 Antigen, Complement Regulatory Protein; Trophoblast Leukocyte Common Antigen; Membrane Cofactor Protein; MCP; Trophoblast-Lymphocyte Cross-Reactive Antigen; Complement Membrane Cofactor Protein; Trophoblast Leucocyte Common Antigen; Measles Virus Receptor; CD46 Antigen; CD46 |
| Gene ID |
17221 |
| UniProt ID |
O88174 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
