Recombinant Mouse Complement Factor H Protein-N-terminal His Tag(Cat#: CTP-311)
This product is a 34kDa recombinant mouse Factor H protein with a N-terminal His Tag tag expressed in the E.coli. It is availible for Positive Control, Immunogen, WB.
Summary
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Specifications
| Expressed Host |
E.coli |
| Specie Reactivity |
Mouse |
| Target |
Factor H |
| Molecule Mass |
34kDa |
| Purity |
>95 % determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300 |
| Applications |
Positive Control; Immunogen; WB |
| Product Form |
Lyophilized |
| Storage |
Store at -20°C/-80°C. Avoid freeze-thaw cycles. |
Protein Information
| Introduction |
Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. |
| Alternative Names |
Complement Factor H; Age-Related Maculopathy Susceptibility 1; H Factor (Complement); Beta-1H; FHL1 ; Adrenomedullin Binding Protein; Beta-1-H-Globulin; H Factor; Factor H; CFH; FH |
| Gene ID |
12628 |
| UniProt ID |
P06909 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
