CD11c

Background

CD11c, also known as integrin alpha X (ITGAX), is a type I transmembrane glycoprotein encoded by the ITGAX gene in humans. It is predominantly found in monocytes, granulocytes, a specific subset of B cells, dendritic cells, and macrophages. CD11c is crucial in cell-cell and cell-extracellular matrix interactions, facilitating antigen presentation, phagocytosis, and immune cell adhesion. It is also significant in hematologic malignancies such as B-cell chronic lymphocytic leukemia and hairy cell leukemia. These functions highlight CD11c's significance in immune defense and disease pathology, making it a vital marker and potential therapeutic target.

Its Gene ID: 3687, UniProtKB ID: P20702, and OMIM ID: 151510.

Fig.1 Structure of CD11c.Distributed under CC BY-SA 3.0, from Wiki, without modification.

CD11c's Role in Various Diseases

CD11c, an integral immune system component, is implicated in several diseases, ranging from inflammatory and autoimmune disorders to cancers and infectious diseases. In autoimmune conditions such as rheumatoid arthritis and multiple sclerosis, CD11c⁺ cells play a role in inflammation and presenting autoantigens. In infectious diseases, they are crucial for pathogen recognition and immune activation. As a diagnostic marker, CD11c expression is also a hallmark in certain hematologic malignancies, such as B-cell chronic lymphocytic leukemia and hairy cell leukemia. Additionally, CD11c+ cells in the tumor microenvironment can support immune surveillance or facilitate immune evasion in cancers. The elevated cytotoxic potential of CD11c⁺ CD8⁺ T cells further underscores the role of CD11c in immune responses. These diverse functions make CD11c a key player in disease pathology and a promising therapeutic target.

CD11c Antibodies

CD11c is an essential immune system protein involved in phagocytosis, cell adhesion, immunological surveillance, and antigen presentation. Its expression on dendritic cells and other immune cells makes it a useful marker and potential therapeutic target in various medical diseases. CD11c antibodies are frequently utilized in research for multiple applications, including cell identification, immunophenotyping, and functional immune response studies.

CD11c Functional Service

Creative Biolabs provides a wide array of products related to CD11c, featuring ELISA assay kits, anti-CD11c antibodies, and recombinant CD11c proteins. These tools are designed to precisely identify and monitor interactions between human CD11c protein and other factors. They are essential components in studies focused on creating therapeutic strategies for a range of diseases.

Fig.2 Expression levels of Phospho-Erk1 and CD11c in B lymphocytes.¹

CD11c, traditionally recognized as a dendritic cell marker, has recently been implicated in modulating neutrophil and T cell activities. Researchers observed diminished B cell counts in CD11c knockout mice, prompting an investigation into B cell development. Utilizing anti-CD11c antibodies in flow cytometry, researchers identified a marked reduction in recirculating and mature B cells in CD11c KO mice, linked to increased proliferation and apoptosis. Considering the absence of CD11c expression in these B cells, the study proposed a non-intrinsic regulatory role through dendritic cells, leading to altered macrophage migration inhibitory factor (MIF) levels. This highlights CD11c’s novel involvement in naïve B cell survival.

Creative Biolabs provides an extensive range of services focused on CD11c functionality, featuring specialized assays for investigating CD11c interactions along with customized functional evaluations. Additionally, researchers excel in delivering comprehensive CD11c antibody services that accommodate the varied requirements of the research community. Their bespoke solutions, combined with committed support, ensure that each endeavor is aligned with the client’s precise objectives, thereby driving progress in immunological studies and the innovation of new therapeutic approaches.

Reference

1. Hou, Lifei, et al. "Integrin CD11c regulates B cell homeostasis." Frontiers in Immunology 15 (2024): 1359608. Distributed under Open Access license CC BY 4.0, without modification.