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Cyclic Nucleotide-gated Cation Channel Family

Cyclic nucleotide-gated (CNG) channels, which belong to the superfamily of voltage-gated channels where the motion of the α-helix S6 controls gating in most of its members, mediate transduction in several sensory neurons. CNG channels are composed of 4 subunits, either of type alpha (CNGA1, CNGA2, CNGA3, CNGA4) or of type beta (CNGB1 and CNGB3) in mammals. These CNG channels use the free energy of cyclic nucleotides’ (CNs’) binding to open the pore, a process known as gating. Gating of CNG channels is initiated by the binding of CNs to the cyclic nucleotide-binding (CNB) domain and terminated with the opening of the gate located in the pore region, approximately some tens of Å apart. CNG channels play a vital role in signaling in the primary sensory cells of the vertebrate visual and olfactory systems.

In conclusion, CNG channels are important in the function of various sensory pathways such as vision and olfaction, as well as in other vital cellular functions including hormone release and chemotaxis. Here show the cyclic nucleotide-gated cation channel family members in human that you may be interested in.

Human Cyclic Nucleotide-gated Cation Channel 1 Members
CNGA1 CNGA2 CNGA3
CNGA4 CNGB1 CNGB3

Using our Magic™ membrane protein production platform, scientists at Creative Biolabs devote themselves to providing the preparation services of these targets in required formats using various strategies, including detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, with the stable cell line.

Magic™ membrane protein production platform – Creative Biolabs

Moreover, our Magic™ membrane protein antibody discovery platform can also assist in discovering antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, and etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.


All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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