shRNA Adenovirus Serotype 5 (ΔE1/E3), pH1-(NLRP9-shRNA-Seq2)(CAT#: AdV-SI2366WQ)
This product is a NLRP9-shRNA encoding AdV, which is based on AdV-5 serotype with E1/E3 gene deleted. The protein encoded by NLRP9 gene belongs to the NALP protein family. This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. The expression of NLRP9-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
| Specifications | |
|---|---|
| Family | Adenoviridae |
| Species | Adenovirus |
| Serotype | AdV-5 |
| Backbone | AdV-5 (ΔE1/E3) |
| Tropism | Both nondividing and dividing cells |
| Modification | ΔE1/E3 |
| Insert | NLRP9-shRNA-Seq2 |
| Related Target/Protein | NLRP9 |
| Region | 3UTR |
| TargetSeq | CGTCTCACAAAGGCTTTCCTT |
| NCBI RefSeq | NM_176820 |
| Alternative Names | NOD6; NALP9; PAN12; CLR19.1 |
| Titer | >1*10^10 GC/mL |
| Related Diseases | Immune system disease |
