Ligand-retargeted Lentiviral Vector Service
As a number of lentiviral vectors have been gradually developed, Creative Biolabs is helping our customers with gene therapeutic strategy basing on our deep analytical capabilities and vast experience in lentiviral vectors. Our client-focused, integrated team will anticipate challenges, overcome difficulties and successfully modify lentiviral vectors by various ligands or receptors to target a range of cell types. We guarantee the finest results for our customers all over the world.
Introduction of Lentiviral Vector
Gene therapy is an attractive method for transferring specific genes into loss-of-function cells, which plays a critical role in treating a variety of diseases. Previous studies indicate that lentiviral vector has become one of the most popular delivery systems and can provide long-term and stable transduction in various cell types. Meanwhile, current researchers have focused on expanding the potential tropism and improving the targeted specificity of lentiviral vectors. Many attempts have been taken to using ligands, peptides, or antibodies to recognize target cells. In addition, another strategy has been developed which is based on the recognition or binding of ligands and receptors. For instance, the EGF receptor (EGFR) has been used as a ligand-retargeted receptor of lentiviral vector, and the data suggest that this receptor has a high titer and can specifically target many types of cells or tissues. Furthermore, some sites of envelope glycoproteins have been also modified for helping the binding of different species of virus receptors to the cell surface.
Figure 1. The HIV-1 Lentiviral Vector. (Sakuma, 2012)
Services
Vectors derived from lentiviruses have been regarded as powerful tools in gene transfer for numerous disease therapy. To date, the interaction between ligands and many cell receptors has aroused much attention due to the high transfection efficiency. As a consequence, Creative Biolabs provides a wide spectrum of ligand-retargeted lentiviral vector services to improve the specificity and efficacy of gene therapy. We have successfully accomplished a number of lentiviral vector-based programs for our worldwide customers. Specifically, a series of ligands have been widely used in receptor-mediated lentiviral vectors targeting different cell types. For example, transferrin has been generated in lentiviral vectors to trigger the expression of glioma epithelial cells. Additionally, more recent studies conducted by our labs demonstrate that ligands, including mannose, lectins, folate, α2 macroglobulin, and cholera toxin subunit B, play an important role in modifying lentiviral vector targeting various malignant cells. In our company, our scientists specialized in lentiviral vector studies will work with you to develop a most appropriate strategy that will offer the most meaningful data for your research.
Creative Biolabs is dedicated to delivering high-quality, high titer lentivirus or lentiviral vector products to expand cutting edge research across a range of applications. With our proven competencies and regulatory expertise, we are therefore confident in offering the best ligand-retargeted lentiviral vectors. We can provide many flexible options, from which you can always find a better match for your particular project. If you are interested in our services, please contact us for more details.
Reference
- Sakuma, T.; et al. (2012). Lentiviral vectors: basic to translational. Cancer Cell. 443(3): 603-18.
