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IP3 Receptor Family

Inositol 1,4,5-trisphosphate receptor (InsP3R, IP3R) family is a group of membrane glycoprotein complexes functioning as an intracellular Ca2+ channel that mediates calcium release from the endoplasmic reticulum (ER), which is activated by inositol 1,4,5-trisphosphate (InsP3, IP3). IP3 receptors are very diverse among organisms and are involved in the regulation of epithelial secretion of electrolytes and fluid by the interaction with AHCYL1. They represent dominant second messengers inducing the release of Ca2+ from intracellular store sites. IP3 receptors are suggested to play a role in ER stress-induced cell apoptosis. Cytoplasmic calcium released from the ER induces cell apoptosis by the activation of CaM kinase II, eventually resulting in the activation of downstream apoptosis pathways.

IP3 receptors are also involved in some physiological processes such as fertilization, development, behavior, learning, and memory. And they are suggested to be important to the study of skeletal muscle development, health, and disease. We're concerned here with several IP3 receptors in human that you might be interested in.

Human IP3 receptor Members
ITPR1 ITPR2 ITPR3

Benefited by our Magic™ membrane protein production platform, scientists at Creative Biolabs spare no effort to provide the protein preparation services of these membrane proteins mentioned above in required formats through different strategies, including detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, with stable cell line.

Magic™ membrane protein production platform – Creative Biolabs

Furthermore, Magic™ membrane protein antibody discovery platform at Creative Biolabs can be used for developing antibodies against these targets, even fully humanized antibodies, by various approaches such as hybridoma technology, phage display technology, and etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for technical help.


All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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