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Junctophilin Family

Junctophilin (JPH) family is a group of junctional membrane complex (JMC)-associated proteins existed in all excitable cells from striated muscle to neurons. Members of JPH family consist of specific protein domains. The family includes eight amino-terminal membrane occupation and recognition nexus (MORN) motifs separated by a joining region, followed by an alpha helix, divergent, and a C-terminal transmembrane motif that anchors the protein into the endoplasmic reticulum (ER) or sarcoplasmic reticulum (SR). JHPs are involved in the formation of JMCs which connect the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. And they provide a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.

The link between these proteins and its critical roles in all excitable cells indicate the implications of junctophilins for human physiology and pathophysiology. JHPs hold the promise of novel therapeutic targets and molecular interventions for a number of these diseases. Below are some junctophilins that we have made detailed introductions for your review.

Human Junctophilin Members
JPH1 JPH2 JPH3 JPH4

By utilizing our Magic™ membrane protein production platform, scientists at Creative Biolabs are experts in providing the preparation services of these targets in required formats using various strategies, including detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, with the stable cell line.

Magic™ membrane protein production platform – Creative Biolabs

Moreover, our Magic™ membrane protein antibody discovery platform can also assist in discovering antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, and etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.


All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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