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Magic™ Membrane Protein Human PIGA (Phosphatidylinositol glycan anchor biosynthesis class A) Full Length (CAT#: MPC4124K) Made to Order

Datasheet
This product is a made-to-order Human PIGA membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PIGA
  • Protein Length
  • Full length
  • Protein Class
  • Transferase
  • TMD
  • 1
  • Sequence
  • MACRGGAGNGHRASATLSRVSPGSLYTCRTRTHNICMVSDFFYPNMGGVE
    SHIYQLSQCLIERGHKVIIVTHAYGNRKGIRYLTSGLKVYYLPLKVMYNQ
    STATTLFHSLPLLRYIFVRERVTIIHSHSSFSAMAHDALFHAKTMGLQTV
    FTDHSLFGFADVSSVLTNKLLTVSLCDTNHIICVSYTSKENTVLRAALNP
    EIVSVIPNAVDPTDFTPDPFRRHDSITIVVVSRLVYRKGIDLLSGIIPEL
    CQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLV
    QGHIFLNTSLTEAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLIILCEP
    SVKSLCEGLEKAIFQLKSGTLPAPENIHNIVKTFYTWRNVAERTEKVYDR
    VSVEAVLPMDKRLDRLISHCGPVTGYIFALLAVFNFLFLIFLRWMTPDSI
    IDVAIDATGPRGAWTNNYSHSKRGGENNEISETR

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • PIGA
  • Full Name
  • Phosphatidylinositol glycan anchor biosynthesis class A
  • Introduction
  • This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12.
  • Alternative Names
  • PIGA; GPI3; PNH1; PIG-A; MCAHS2; GLCNAC-PI synthesis protein; GPI anchor biosynthesis; class A GlcNAc-inositol phospholipid assembly protein; phosphatidylinositol-glycan biosynthesis, class A protein; Phosphatidylinositol glycan anchor biosynthesis class A

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