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Magic™ Antibody Discovery - Human Integrin alpha V beta 3 (31-992(ITGAV)&27-718(ITGB3)) Membrane Protein, Partial, -His Tag & Tag free (CAT#: MP0307F)

Datasheet
This membrane protein is Human Integrin alpha V beta 3 (31-992(ITGAV)&27-718(ITGB3)). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Integrin alpha V beta 3
  • Protein Length
  • ECD
  • Molecular Weight
  • Calculated MW of 112.9 kDa (ITGAV) and 81.8 kDa (ITGB3). The non-reducing (NR) protein migrates as 120-145 kDa (ITGAV) and 85-95 kDa (ITGB3) respectively due to glycosylation.
  • Sequence
  • AA Phe 31 - Val 992 (ITGAV) & Gly 27 - Asp 718 (ITGB3) (Accession # NP_002201.1 (ITGAV) & NP_000203.2 (ITGB3)).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA
  • Expression Systems
  • HEK293
  • Tag
  • ITGAV is fused with an acidic tail at the C-terminus, and followed by His tag and subunit ITGB3 contains no tag but a basic tail at the C-terminus.
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Integrin alpha V beta 3
  • Full Name
  • integrin subunit alpha V & integrin subunit beta 3
  • Introduction
  • The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. & The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
  • Alternative Names
  • CD51; MSK8; VNRA; VTNR; integrin alpha-V; antigen identified by monoclonal antibody L230; integrin alphaVbeta3; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); vitronectin receptor CD51; MSK8; VNRA; VTNR; integrin alpha-V; antigen identified by monoclonal antibody L230; integrin alphaVbeta3; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); vitronectin receptor subunit alpha & GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16; integrin beta-3; antigen CD61; integrin beta 3; integrin beta chain, beta 3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); platelet membrane glycoprotein IIIa

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