SLC19A1 Membrane Protein Introduction

Introduction of SLC19A1

The solute family 19, member 1, is a protein which in humans is encoded by the SLC19A1 gene. It is also named as SLC19A1, Intestinal folate carrier 1(IFC-1), Placental folate transporter or Reduced folate carrier protein (RFC). It is a transporter for folate intake. Folate uptake in human placental chorion cells is produced by a new mechanism called potocytosis. The potocytosis consists of three functional components, the folate receptor, the folate transporter, and the v-type H⁺-pump. Transport of folate compounds into mammalian cells can be mediated by receptors (see folate receptor 1) or vector-mediated mechanisms. Functional coordination between these two mechanisms is considered to be a method of folate uptake in certain cell types.

Basic Information of SLC19A1
Protein Name	Folate transporter 1 (FOLT)
Gene Name	SLC19A1
Aliases	Intestinal folate carrier 1(IFC-1), Placental folate transporter, Reduced folate carrier protein (RFC), Solute carrier family 19 member 1
Organism	Homo sapiens (Human)
UniProt ID	P41440
Transmembrane Times	12
Length (aa)	591
Sequence	MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQLMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRVSFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGHALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTNSARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPSSIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSDVRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKAAQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPVTTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ

Function of SLC19A1 Protein

SLC19A1 plays a role in maintaining the intracellular concentration of folic acid. People with a specific polymorphism of SLC19A1 (c.80 GG) have lower levels of folate. Methotrexate (MTX) is an anti-folate chemotherapeutic drug that is actively transported by a carrier-mediated absorption system. Other studies have also shown that people who carry c.80AA Polymorphic polymorphisms treated with methotrexate have higher levels of anti-folate chemotherapy drugs. Therefore, depending on the patient's genotype, a personalized dose of the drug may be necessary.

Fig.1 The structure of SLC19A1 Protein.

Application of SLC19A1 Protein in Literature

Kotnik, B. F., et al. Association between SLC19A1 Gene Polymorphism and High Dose Methotrexate Toxicity in Childhood Acute Lymphoblastic Leukaemia and Non Hodgkin Malignant Lymphoma: Introducing a Haplotype Based Approach. Radiology and Oncology.2017 (51.4): 455–462. PubMed ID: 29333125

These results suggest that SLC19A1 SNP and haplotype analysis can provide personalized HD-MTX treatment for children with ALL /NHML for better therapeutic results.
Imamura H., et al. Impaired NFKBIE Gene Function Decreases Cellular Uptake of Methotrexate by down-Regulating SLC19A1 Expression in a Human Rheumatoid Arthritis Cell Line. Modern Rheumatology. 2016 (26.4): 507–516. PubMed ID: 26587663

The authors believe that damage to the function of the NFKBIE gene can reduce the uptake of cells by MTX, suggesting that this gene is an important factor in the outcome of RA.
Cai C., et al. Association of MTHFR, SLC19A1 Genetic Polymorphism, Serum Folate, Vitamin B₁₂ and Hcy Status with Cognitive Functions in Chinese Adults. Nutrients. 2016,8(10):665. PubMed ID: 27783031

This article reveals that cognition of adults is involved in MTHFR, SLC19A1 gene polymorphism and serum Hcy levels.
Mahmuda N.A., et al. A Study of Single Nucleotide Polymorphisms of the SLC19A1/RFC1 Gene in Subjects with Autism Spectrum Disorder. International Journal of Molecular Sciences. 2016,17(5):772. PubMed ID: 27213354.

Although these findings support the role of the SLC19A1 gene in the etiology of ASD, it is not an important risk factor for ASD samples analyzed in this study.
Zhang C., et al. Hypermethylation of Protocadherin Γ Subfamily A12 and Solute Carrier Family 19 A 1 Promoters Contributes to the Occurrence and Metastasis of Colorectal Cancer. Oncology Letters .2018,15 (6): 8215–8222. PubMed ID: 29805555

These results indicate that hypermethylation of the PCDH-γ-A12 and SLC19A1 promoters perhaps lead to the occurrence and metastasis of colorectal cancer in the Chinese Han population.

SLC19A1 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC19A1 antibody development services.

Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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