SLC5A9 Membrane Protein Introduction

Introduction of SLC5A9

SLC5A9 (solute carrier family 5 member 9), also known as SGLT4, is a Na⁺-dependent glucose transporter. It consists of 14 transmembrane helices and 706 amino acid residues. This protein belongs to the solute carrier family 5. Among the SLC5A family members, SGLTs (SGLT1/SLC5A1, SGLT2/SLC5A2, and SGLT3/SLC5A4) have been widely investigated. These members are involved in the sugar absorption/reabsorption in the mammalian body. Recent studies report SLC5A9 is also an essential Na⁺-dependent glucose transporter, involved in the absorption and/or reabsorption of mannose, 1,5-anhydro-D-glucitol, and fructose.

Basic Information of SLC5A9
Protein Name	Sodium/glucose cotransporter 4
Gene Name	SLC5A9
Aliases	SGLT4
Organism	Homo sapiens (Human)
UniProt ID	Q2M3M2
Transmembrane Times	14
Length (aa)	706
Sequence	MSKELAAMGPGASGDGVRTETAPHIALDSRVGLHAYDISVVVIYFVFVIAVGIWSSIRASRGTIGGYFLAGRSMSWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEWNMRKSRSGGDRGIHPRSHGRTGVRSQATWLLLALGWVFVPVYIAAGVVTMPQYLKKRFGGQRIQVYMSVLSLILYIFTKISTDIFSGALFIQMALGWNLYLSTGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPNVTVPNTTCHLPRPDAFHILRDPVSGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPDEVGCVDPDVCQRICGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTEQELMVVGRVFVVFLVVISILWIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRMILEFSYPAPACGEVDRRPAVLKDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTRLTWWTRNCPLSELEKEAHESTPEISERPAGECPAGGGAAENSSLGQEQPEAPSRSWGKLLWSWFCGLSGTPEQALSPAEKAALEQKLTSIEEEPLWRHVCNINAVLLLAINIFLWGYFA

Function of SLC5A9 Membrane Protein

The pathways related SLC5A9 include transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Hexose transport. SLC5A9/SGLT4 has been reported to act as a new Na⁺-dependent glucose transporter, responsible for absorption/reabsorption of mannose, 1,5-anhydro-D-glucitol (1,5-AG), and fructose. The SLC5A9 mRNA is mainly expressed in the small intestine and kidney. Results from colorectal cancer (CRC) genome-wide association study showed two variants located near the SLC5A9 and DUSP4 loci are present in CRC patients, suggesting a possible association between SLC5A9 and CRC. Furthermore, SLC5A9 may be a novel candidate gene in the development of proliferative diabetic retinopathy.

Fig.1 The interaction between SLC5A9 protein and other proteins.

Application of SLC5A9 Membrane Protein in Literature

Tazawa S., et al. SLC5A9/SGLT4, a new Na⁺-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose. Life Sciences. 2005, 76(9): 0-1050. PubMed ID: 15607332

The results of in vitro study show that SLC5A9 exerts unique physiological functions in absorption and/or reabsorption of Man, 1,5AG, and Fru.
Ung C., et al. Whole exome sequencing identification of novel candidate genes in patients with proliferative diabetic retinopathy. Vision research. 2017, 139: 168-176. PubMed ID: 28431867

This study shows that rare non-synonymous variants in FAM132A, SLC5A9, ZNF600, and TMEM217 contribute to the development of proliferative diabetic retinopathy (PDR).
Fernandez-Rozadilla C., et al. A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12. BMC Genomics. 2013, 14: 55. PubMed ID: 23350875

Two new susceptibility variants at 1p33 and 8p12 loci have been identified by performing GWAS in a Southern European population with CRC. Moreover, the two variants are located near the SLC5A9 and DUSP4 loci, which are good functional candidates for the association signals.

SLC5A9 Preparation Options

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