Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsSolute carrier family 5 (SLC5), also known as the sodium-glucose linked transporter (SGLT), is a family of glucose transporters that mediate the transport of glucose and structurally related substances across cellular membranes. This family has 12 human genes expressed in tissues ranging from epithelia to the central nervous system. Among the 12 transporters, 10 are tightly coupled plasma membrane Na(+)/substrate cotransporters for solutes such as glucose, myoinositol, and anions; 1 is a Na(+)/Cl(-)/choline cotransporter; and another is a glucose activated ion channel. Besides, members of the SLC5 family are multifunctional membrane proteins in that they also behave as uniporters, urea and water channels, and urea and water cotransporters.
The SCL5A1 and SCL5A2 are the two most well-known members of SLC5. SLC5A3 is a sodium/myo-inositol cotransporter while SLC5A5 is a sodium/iodide cotransporter. SLC5A6 is also known as the sodium-dependent multivitamin transporter, a putative transporter for uptake of biotin and pantothenic acid at the blood-brain barrier. SLC5A7 is called the high-affinity choline transporter that carries choline into acetylcholine-synthesizing neurons. SLC5A8 is a high-affinity sodium-coupled transporter for short-chain fatty acids while SCL5A9 is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose. The other members of SCL5 are less studied.
Herein, we give an introduction to the following human SLC5 members focusing on their structure, transport mechanisms, function, and pharmaceutical potential/applications.
| Human Solute Carrier Family 5 Members | |||
| SLC5A1 | SLC5A10 | SLC5A11 | SLC5A12 |
| SLC5A2 | SLC5A3 | SLC5A4 | SLC5A5 |
| SLC5A6 | SLC5A7 | SLC5A8 | SLC5A9 |
Membrane proteins are stable in their native lipid environment. To enable structural and functional investigations, they need to be extracted from the membrane. Aided by our cutting-edge Magic™ membrane protein production platform, Creative Biolabs now offers the most comprehensive membrane protein preparation services to facilitate their isolation toward fundamental structural and functional research as well as drug discovery applications. Specifically, we can reconstitute your proteins in systems such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, and polymers. Some membrane proteins require specific lipids for optimal activity, and thus we also provide lipid screening services.
Moreover, aided by our Magic™ membrane protein antibody discovery platform, we can offer antibody discovery services against these membrane protein antigens presenting in near-native conformations. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more detailed information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
