SLC9B2 Membrane Protein Introduction

Introduction of SLC9B2

SLC9B2 (sodium/hydrogen exchanger 9B2) is also known as NHA2 or NHEDC2. It is encoded by the SLC9B2 gene in humans and belongs to solute carrier family 9, subfamily B. SLC9B2 is broadly expressed in brain, liver and 21 other tissues. It functions as a sodium/hydrogen antiporter and converts the proton motive force into sodium gradients. Also, SLC9B2 is involved in signal transduction and drug efflux.

Basic Information of SLC9B2
Protein Name	Sodium/hydrogen exchanger 9B2
Gene Name	SLC9B2
Aliases	NHA2, NHEDC2
Organism	Homo sapiens (Human)
UniProt ID	Q86UD5
Transmembrane Times	12
Length (aa)	537
Sequence	MGDEDKRITYEDSEPSTGMNYTPSMHQEAQEETVMKLKGIDANEPTEGSILLKSSEKKLQETPTEANHVQRLRQMLACPPHGLLDRVITNVTIIVLLWAVVWSITGSECLPGGNLFGIIILFYCAIIGGKLLGLIKLPTLPPLPSLLGMLLAGFLIRNIPVINDNVQIKHKWSSSLRSIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAHYLLGLPWQWGFILGFVLGAVSPAVVVPSMLLLQGGGYGVEKGVPTLLMAAGSFDDILAITGFNTCLGIAFSTGSTVFNVLRGVLEVVIGVATGSVLGFFIQYFPSRDQDKLVCKRTFLVLGLSVLAVFSSVHFGFPGSGGLCTLVMAFLAGMGWTSEKAEVEKIIAVAWDIFQPLLFGLIGAEVSIASLRPETVGLCVATVGIAVLIRILTTFLMVCFAGFNLKEKIFISFAWLPKATVQAAIGSVALDTARSHGEKQLEDYGMDVLTVAFLSILITAPIGSLLIGLLGPRLLQKVEHQNKDEEVQGETSVQV

Function of SLC9B2 Membrane Protein

SLC9B2 is also known as NHA2 which belongs to proton exchangers and transporters. It was identified broadly expressed in the brain, liver, and some other tissues. SLC9B2 is shown to convert the proton motive force into sodium gradients, which is associated with energy-requiring processes. Also, it is involved in environmental signal transduction and drug efflux. Its family - SLC9B proteins (including SLC9B2 and SLC9B2) belong to the members of the sodium/lithium hydrogen antiporter family, and they play the functions as solute exchangers within cellular membranes of mammalian tissues. SLC9B2 is involved in the metabolism of the skeletal system, and it can be as a biomarker for bone homeostasis indicator of Arabians. In addition, SCL9B2 plays the electrogenic transporting role dependent on a lysine residue in the transmembrane domain. Moreover, SLC9B2 is necessary for survival, and show different transporting functions compared with SLC9B1. Furthermore, SLC9B2 deficiency can enhance aging and obesity-induced glucose intolerance in mice.

Fig.1 SLC9B2 acts as a Na⁺/H⁺ exchanger. (Chintapalli, 2015)

Application of SLC9B2 Membrane Protein in Literature

Stefaniuk-Szmukier M., et al. Transcriptomic hallmarks of bone remodelling revealed by RNA-Seq profiling in blood of Arabian horses during racing training regime. Gene. 2018. PubMed ID: 30021131

This article indicates that SLC9B2 is involved in the metabolism of the skeletal system, and it can be as a biomarker for bone homeostasis indicator of Arabians.
Holmes R.S., et al. Evolution of Vertebrate Solute Carrier Family 9B Genes and Proteins (SLC9B): Evidence for a Marsupial Origin for Testis Specific SLC9B1 from an Ancestral Vertebrate SLC9B2 Gene. J Phylogenetics Evol Biol. 2014, 4(3). PubMed ID: 28868326

This article shows the identity between SLC9B1 and SLC9B2 and indicates that SLC9B1 originates from SLC9B2.
Uzdavinys P., et al. Dissecting the proton transport pathway in electrogenic Na⁺/H⁺ antiporters. Proc Natl Acad Sci U S A. 2017, 114(7): E1101-E1110. PubMed ID: 28154142

This article demonstrates that a lysine residue in the transmembrane domain is necessary for electrogenic transport in sodium/hydrogen antiporter - SCL9B2.
Chintapalli V.R., et al. Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities. Proc Natl Acad Sci U S A. 2015, 112(37): 11720-5. PubMed ID: 26324901

This article shows that SLC9B2 and SLC9B2 are necessary for survival, and shows different transporting functions.
Deisl C., et al. Loss of Sodium/Hydrogen Exchanger NHA2 Exacerbates Obesity- and Aging-Induced Glucose Intolerance in Mice. PLoS One. 2016, 11(9): e0163568. PubMed ID: 27685945

This article shows that SLC9B2 deficiency enhances aging and obesity-induced glucose intolerance in mice, also it indicates the relationship between SLC9B2 expression and insulin secretion capacity in islets.

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Reference

Chintapalli V R, et al. (2015). Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities. Proc Natl Acad Sci U S A. 112(37): 11720-5.

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