Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe sodium/hydrogen exchangers (NHE) are among the main regulators of cell volume and intracellular concentration of hydrogen and sodium ions. They transport sodium out of the cell, and hydrogen into the cell. They are expressed on the membranes of many cells, especially those in the nephron of the kidney. These transporter proteins play an important role in intracellular pH and cell volume regulation, cell growth, and differentiation, stimulus-response coupling with white cells and platelets, the metabolic response to hormones like insulin and glucocorticoids, and the transepithelial absorption and secretion of sodium, hydrogen, bicarbonate and chloride ions, and organic anions. Alteration in the function of NHEs may lead to diverse human diseases such as kidney failure, cardiovascular diseases, cancer, and many brain diseases like epilepsy, Alzheimer's disease, neuropathic pain and ischemia/reperfusion-induced cerebral injury. Clinically, inhibitors of these transporters that prevent myocardial infarction and other heart diseases like congestive heart failure have been developed. Moreover, in preclinical animal models NHE inhibitors (e.g., amiloride and cariporide) produce protective effects on ischemia/reperfusion-induced brain injury (e.g., stroke), exhibit good antiepileptic potential and attenuate neuropathic pain.
Here, we present an introduction of the following human NHE transporter proteins concerning the substrate specificity, regulation, physiological roles, and pathophysiological roles. Some of these proteins are less well-characterized and their mechanisms and functions remain to be further investigated using more advanced techniques.
| Human Sodium/Hydrogen Exchanger Family Members | |||
| SLC9A1 | SLC9A2 | SLC9A3 | SLC9A4 |
| SLC9A5 | SLC9A6 | SLC9A7 | SLC9A9 |
| SLC9B1 | SLC9B2 | SLC9C1 | |
To aid in the in vitro structural and functional characterization of membrane proteins, Creative Biolabs proudly introduces our Magic™ membrane protein production platform to our clients. At the cutting edge of membrane protein production field, we are capable of using various strategies and approaches to reconstitute your proteins into different functional formats, including detergent micelles, proteoliposomes, nanodiscs, lipoparticles, and polymers. Among them, polymers yield preparations of membrane proteins that would be both functional and soluble in surfactant-free aqueous solutions.
Additionally, aided by our Magic™ membrane protein antibody discovery platform, we are a reliable partner to help you in your anti-membrane protein antibody discovery projects. We also present DNA immunization service for anti-membrane protein antibody development. If you are interested in any of our services, please contact us to discuss your requirements.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
