Premade Antibody Library based TCR-Like Antibody Discovery Service

As an industry leading expert in premade antibody library screening, Creative Biolabs is committed to discovering numerous antibodies against specific targets for both scientific and clinical purposes. Our experienced scientists and technicians can help global customers discover high affinity TCR-like antibody from our premade phage displayed antibody library.

TCR-Like Antibody

T cell receptor (TCR)-like/mimic antibodies are a specific group of antibodies targeting tumor-specific antigens that control cell growth, proliferation, and death. Like authentic TCRs, TCR-like antibodies recognize the peptide/MHC complexes on the tumor cell surfaces and thus trigger broad pharmacological pathways, such as ADCC, CDC, antibody-dependent cellular phagocytosis (ADCP), or the direct induction of apoptosis. In addition, TCR-like antibodies can be converted to a chimeric antigen receptor (CAR) structure to mediate the specific recognition of tumor cells by T cells, such as CAR-T cells. Currently, numerous TCR-like antibodies have been developed as in vitro tools to detect the expressed tumor or viral-related MHC/peptide complexes on the surface of primary tumor cells and metastases or viral infected cells, antigen-presenting cells, etc.

TCR-Like Antibody Discovery from Premade Phage Displayed Antibody Library Fig.1 The molecular mechanisms of TCR-like antibodies against tumor cells.^{1, 2}

Premade Phage Displayed Antibody Library Screening for TCR-Like Antibody Discovery

Antibodies with MHC-restricted specificity of T cells have been traditionally rare and difficult to generate. A major breakthrough in making TCR-like antibodies was achieved when phage display technology has been developed. As a well-recognized expert at phage display technology, Creative Biolabs has constructed numerous native, immunization, and synthetic phage displayed antibody libraries with great capacity & diversity that can derive high affinity antibodies ranging from 10 pM to 10 nM. Our professional scientists will help you select the most appropriate ready-to-use antibody library to directly obtain specific binders in a time-saving manner. The premade phage displayed antibody libraries available at Creative Biolabs include:

Libraries	Library ID	Display Technology	Library Format	Species	Library Size
Phage display human scFv libraries	HuScL-2	Phage Display	scFv	Human	1.42×10⁹
	HuScL-4	Phage Display	scFv	Human	2.0×10⁹
	HuScL-6	Phage Display	scFv	Human	1.0×10¹¹
	HuScL-7	Phage Display	scFv	Human	1.1×10¹⁰
Phage display human Fab libraries	HuFabL-4	Phage Display	Fab	Human	1.9×10¹⁰
	HuFabL-5	Phage Display	Fab	Human	1.1×10¹⁰
	HuFabssL-1	Phage Display	Fab	Human	1.8×10¹⁰

Creative Biolabs also provides antibody discovery services for different types of targets to suit a variety of applications:

Advantages of Our Premade Library Screening Service

One-stop TCR-like antibody discovery service from MHC/peptide complex preparation to scale-up monoclonal antibody production and characterization
Flexible options to satisfy every client's specific requirement
Professional scientific team which ensures the highest success rate of each project
Short turnaround time with relatively low price

Creative Biolabs offers our worldwide clients the best phage displayed antibody library screening services through our excellent biopanning strategies and state-of-the-art equipment. In addition to TCR-like antibody discovery, we also offer other epitope antibody discovery services from premade phage displayed antibody library, such as anti-idiotype and anti-PTM antibody discovery. If you are interested in our service, please feel free to contact us by e-mail and our team will get back to you as soon as possible.

References

He, Q., et al. 2019. TCR-like antibodies in cancer immunotherapy. Journal of hematology & oncology, 12(1), p.99.
under Open Access license CC BY 4.0, without modification.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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