ANGPT2

ANGPT2 is a protein that in humans is encoded by ANGPT2 gene. Angiopoietin 2 (ANG-2) is an angiogenic peptide released by endothelial cells, which plays an essential role in modulating angiogenesis and vascular homeostasis. It binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. It can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

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