HAVCR2
HAVCR2 is a protein that in humans is encoded by HAVCR2 gene. HAVCR2 belongs to TIM family cell surface receptor proteins. These proteins share a similar structure, in which the extracellular region consists of membrane distal single variable immunoglobulin domain (IgV) and a glycosylated mucin domain of variable length located closer to the membrane. Intracellular domain of HAVCR2 is called C-terminal cytoplasmic tail. It contains five conserved tyrosine residues that interact with multiple components of T-cell receptor (TCR) complex and negatively regulates its function. HAVCR2 is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein (LAG3) mediate the CD8+ T-cell exhaustion.| CAT | Product Name | Source | Product Overview | Target | Type | Datasheet | Size | Price |
|---|---|---|---|---|---|---|---|---|
| VAng-Cr3813 | Recombinant HAVCR2 Protein (Met1-Arg200) [His] | Mammalian cells | Recombinant HAVCR2 Protein (Met1-Arg200) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 40 kDa. (Uniprot ID: Q8TDQ0) | HAVCR2 | Tumor Antigens |  |
100 µg | Inquiry |
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
