ICOS
ICOS is a CD28-superfamily costimulatory molecule that is expressed on activated T cells. It is thought to be important for Th2 cells in particular. The protein encoded by ICOS gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses and regulation of cell proliferation. The increase served as a pharmacodynamic biomarker of anti-CTLA-4 treatment. An agonistic stimulus for the ICOS pathway during anti-CTLA-4 therapy resulted in an increase in efficacy that is about four to five times as large as that of control treatments.| CAT | Product Name | Source | Product Overview | Target | Type | Datasheet | Size | Price |
|---|---|---|---|---|---|---|---|---|
| VAng-Cr3811 | Recombinant ICOS Protein (Met1- Lys140) [Fc] | Mammalian cells | Recombinant ICOS Protein (Met1- Lys140) fused with a Fc tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 45 kDa. (Uniprot ID: Q9Y6W8) | ICOS | Tumor Antigens |  |
100 µg | Inquiry |
| VAng-Cr3842 | Recombinant ICOS Protein (Met1- Lys140) [His] | Mammalian cells | Recombinant ICOS Protein (Met1- Lys140) fused with a Fc tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 45 kDa. (Uniprot ID: Q9Y6W8) | ICOS | Tumor Antigens | |
100 µg | Inquiry |
| VAng-1734Lsx | Human ICOS Protein (Glu 21-Leu 144) [Fc] | HEK293 Cells. | Human ICOS (CD278), Fc Tag, is expressed in human 293 cells. (Uniprot ID: Q9Y6W8-1) | ICOS | Tumor Antigens | |
100 µg | Inquiry |
| VAng-1735Lsx | Human ICOS Protein (Glu 21-Phe 141) [His] | HEK293 Cells. | Human ICOS (CD278), His tag, is expressed in human 293 cells. (Uniprot ID: Q9Y6W8-1) | ICOS | Tumor Antigens | |
100 µg | Inquiry |
| VAng-1736Lsx | Human ICOS Protein (Glu 21-Phe 141) [His] [Avi] | HEK293 Cells. | Biotinylated Human ICOS (CD278), His tag and Avi tag, is expressed in human 293 cells. (Uniprot ID: Q9Y6W8-1) | ICOS | Tumor Antigens | |
25 µg | Inquiry |
| VAng-1926Lsx | Mouse ICOS Protein (Glu 21-Leu 144) [Fc] | HEK293 Cells. | Mouse ICOS (CD278), Fc Tag, is expressed in human 293 cells. (Uniprot ID: Q9WVS0-1) | ICOS | Tumor Antigens | |
100 µg | Inquiry |
| VAng-1927Lsx | Mouse ICOS Protein (Glu 21-Leu 144) [His] | HEK293 Cells. | Mouse ICOS (CD278), His Tag, is expressed in human 293 cells. (Uniprot ID: Q9WVS0-1) | ICOS | Tumor Antigens | |
100 µg | Inquiry |
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
