KDR
KDR Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. It also plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades.| CAT | Product Name | Source | Product Overview | Target | Type | Datasheet | Size | Price |
|---|---|---|---|---|---|---|---|---|
| VAng-Cr3775 | Recombinant KDR Protein (Met1-Lys327) [His] | Mammalian cells | Recombinant KDR Protein (Met1-Lys327) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 45-66 kDa. (Uniprot ID: P35968) | KDR | Tumor Antigens |  |
100 µg | Inquiry |
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